Telomere-Associated Protein TIN2 Is Essential for Early Embryonic Development through a Telomerase-Independent Pathway

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Chiang, Y. Jeffrey; Kim, Sahn-Ho; Tessarollo, Lino; Campisi, Judith; Hodes, Richard J.;

TIN2 is a negative regulator of telomere elongation that interacts with telomeric DNA repeat binding factor 1 (TRF1) and affects telomere length by a telomerase-dependent mechanism. Here we show that inactivation of the mouse TRF1-interacting protein 2 (TIN2) gene resul... View more
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