Telomere-Associated Protein TIN2 Is Essential for Early Embryonic Development through a Telomerase-Independent Pathway
Other literature type
Chiang, Y. Jeffrey
Hodes, Richard J.
- Publisher: American Society for Microbiology
Mammalian Genetic Models with Minimal or Complex Phenotypes
TIN2 is a negative regulator of telomere elongation that interacts with telomeric DNA repeat binding factor 1 (TRF1) and affects telomere length by a telomerase-dependent mechanism. Here we show that inactivation of the mouse TRF1-interacting protein 2 (TIN2) gene resul...