Redox process is crucial for inhibitory properties of aurintricarboxylic acid against activity of YopH: virulence factor of Yersinia pestis

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Kuban-Jankowska, Alicja; Sahu, Kamlesh K; Niedzialkowski, Pawel; Gorska, Magdalena; Tuszynski, Jack A; Ossowski, Tadeusz; Wozniak, Michal;
  • Publisher: Impact Journals LLC
  • Journal: Oncotarget, volume 6, issue 21, pages 18,364-18,373 ( eissn: 1949-2553)
  • Publisher copyright policies & self-archiving
  • Identifiers: pmc: PMC4621896
  • Subject: oxygen reduction/oxidation | Pathology Section | YopH | virulence factor inhibition | Research Paper: Pathology | ATA (aurintricarboxylic acid) | protein tyrosine phosphatase inhibitor

YopH is a bacterial protein tyrosine phosphatase, which is essential for the viability and pathogenic virulence of the plague-causing Yersinia sp. bacteria. Inactivation of YopH activity would lead to the loss of bacterial pathogenicity. We have studied the inhibitory p... View more
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