Necrotic Death Pathway in FAS Receptor Signaling

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Matsumura, Hirotaka; Shimizu, Yusuke; Ohsawa, Yoshiyuki; Kawahara, Atsuo; Uchiyama, Yasuo; Nagata, Shigekazu;
(2000)
  • Publisher: The Rockefeller University Press
  • Journal: The Journal of Cell Biology,volume 151,issue 6,pages1,247-1,256 (issn: 0021-9525, eissn: 1540-8140)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC2190580
  • Subject: Original Article | necrosis | mitochondrial membrane potential | apoptosis | Fas | caspase
    mesheuropmc: biological phenomena, cell phenomena, and immunity

A caspase 8–deficient subline (JB6) of human Jurkat cells can be killed by the oligomerization of Fas-associated protein with death domain (FADD). This cell death process is not accompanied by caspase activation, but by necrotic morphological changes. Here, we show that... View more
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