publication . Other literature type . 1997

Chick pineal clock regulates serotonin N-acetyltransferase mRNA rhythm in culture

Bernard, Marianne; Klein, David C.; Zatz, Martin;
Open Access English
  • Published: 07 Jan 1997
  • Publisher: National Academy of Sciences
Melatonin production in the chick pineal gland is high at night and low during the day. This rhythm reflects circadian changes in the activity of serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT; EC, the penultimate enzyme in melatonin synthesis. In contrast to the external regulation of pineal rhythms in mammals by the suprachiasmatic nucleus, rhythmic changes in AA-NAT activity in cultured chick pineal cells are controlled by an oscillator located in the pineal cells themselves. Here we present evidence that the chick pineal clock generates a rhythm in the abundance of AA-NAT mRNA in cultured cells that parallels the rhythm i...
Medical Subject Headings: endocrine systemfungibody regionssense organs
free text keywords: Biological Sciences
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Other literature type . 1997
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