publication . Other literature type . 1997

Chick pineal clock regulates serotonin N-acetyltransferase mRNA rhythm in culture

Bernard, Marianne; Klein, David C.; Zatz, Martin;
Open Access English
  • Published: 07 Jan 1997
  • Publisher: National Academy of Sciences
Abstract
Melatonin production in the chick pineal gland is high at night and low during the day. This rhythm reflects circadian changes in the activity of serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT; EC 2.3.1.87), the penultimate enzyme in melatonin synthesis. In contrast to the external regulation of pineal rhythms in mammals by the suprachiasmatic nucleus, rhythmic changes in AA-NAT activity in cultured chick pineal cells are controlled by an oscillator located in the pineal cells themselves. Here we present evidence that the chick pineal clock generates a rhythm in the abundance of AA-NAT mRNA in cultured cells that parallels the rhythm i...
Subjects
Medical Subject Headings: endocrine systemfungibody regionssense organs
free text keywords: Biological Sciences
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Other literature type . 1997
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