publication . Article . 2011

Peroxiredoxin I regulates the component expression of γ-secretase complex causing the Alzheimer’s disease

Lee, Young Ju; Goo, Jun Seo; Kim, Ji Eun; Nam, So Hee; Hwang, In Sik; Choi, Sun Il; Lee, Hye Ryun; Lee, Eon Phil; Choi, Hae Wook; Kim, Hong Sung; ...
Open Access
  • Published: 01 Dec 2011 Journal: Laboratory Animal Research, volume 27, page 293 (issn: 1738-6055, eissn: 2233-7660, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
Peroxiredoxin I (Prx I) is a member of the peroxiredoxins (Prxs) family, which are antioxidant enzymes that regulate various cellular process via intracellular oxidative signal pathways. In order to investigate the correlation between Prx I and the γ-secretase complex, which causes Alzheimer's disease (AD), the expression level of Prx I was firstly evaluated in an animal model for AD. NSE/hPen-2 transgenic (Tg) mice, which were used as animal model in this study, showed a high level of Pen-2 expression and accumulation of Aβ-42 peptides in the hippocampus of brain. The expression level of Prx I was significantly higher on the mRNA and protein level in the brain ...
Subjects
free text keywords: Chemistry, Cell biology, In vitro, Messenger RNA, Intracellular, Amyloid precursor protein secretase, biology.protein, biology, Enzyme, chemistry.chemical_classification, Transgene, Oxidative phosphorylation, Antioxidant, medicine.medical_treatment, medicine, Original Article, Peroxiredoxin I, γ-secretase complex, Alzheimer's disease, Aβ-42 peptides
Related Organizations
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publication . Article . 2011

Peroxiredoxin I regulates the component expression of γ-secretase complex causing the Alzheimer’s disease

Lee, Young Ju; Goo, Jun Seo; Kim, Ji Eun; Nam, So Hee; Hwang, In Sik; Choi, Sun Il; Lee, Hye Ryun; Lee, Eon Phil; Choi, Hae Wook; Kim, Hong Sung; ...