publication . Other literature type . Article . 2016

T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions

Van de Velde, Lee-Ann; Subramanian, Chitra; Smith, Amber M.; Barron, Luke; Qualls, Joseph E.; Neale, Geoffrey; Alfonso-Pecchio, Adolfo; Jackowski, Suzanne; Rock, Charles O.; Wynn, Thomas A.; ...
  • Published: 30 Nov 2016
  • Publisher: American Society for Biochemistry & Molecular Biology (ASBMB)
Abstract
Abstract Modulation of T cell proliferation and function by immunoregulatory myeloid cells are an essential means of preventing self-reactivity and restoring tissue homeostasis. Consumption of amino acids such as arginine and tryptophan by immunoregulatory macrophages is one pathway that suppresses local T cell proliferation. Using a reduced complexity in vitro macrophage-T cell co-culture system, we show that macrophage arginase-1 is the only factor required by M2 macrophages to block T cells in G1, and this effect is mediated by l-arginine elimination rather than metabolite generation. Tracking how T cells adjust their metabolism when deprived of arginine reve...
Subjects
free text keywords: mTORC1, Biochemistry, Cell cycle checkpoint, Biology, T cell, medicine.anatomical_structure, medicine, Interleukin 21, Cell biology, Interleukin 3, Cytotoxic T cell, Molecular biology, IL-2 receptor, Arginine, Immunology
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue