publication . Article . 2012

Testicular orphan nuclear receptor 4-associated protein 16 promotes non-small cell lung carcinoma by activating estrogen receptor β and blocking testicular orphan nuclear receptor 2.

FANG FANG; QINGFENG ZHENG; JIANZHI ZHANG; BIN DONG; SAINAN ZHU; XIAOYUN HUANG; YANG WANG; BINGTIAN ZHAO; SHAOLEI LI; HONGCHAO XIONG; ...
Open Access English
  • Published: 01 Oct 2012 Journal: Oncology Reports, volume 29, issue 1, pages 297-305 (issn: 1021-335X, eissn: 1791-2431, Copyright policy)
  • Publisher: D.A. Spandidos
Abstract
The possible involvement of estrogen receptors (ERs) and testicular orphan nuclear receptors (TRs) in human non- small cell lung carcinoma (NSCLC) has been suggested, but their precise roles and their relationship remain largely unknown. This study aimed to investigate whether TR4-associated protein 16 (TRA16) regulates the ERβ and TR2 pathways and could be a potential target in NSCLC. We used tissue microarrays including NSCLC tissues (n=154) and negative controls (n=14) to examine the expression of TRA16 and ERβ, and in vitro reporter gene assays, the mammalian two-hybrid method and immunoprecipitation in Cos-1 cells to investigate the relation- ships among TR...
Subjects
free text keywords: Articles, ERβ, testicular orphan nuclear receptor 2, TR4-associated protein 16, non-small cell lung cancer, Cancer Research, Oncology, General Medicine, Estrogen receptor beta, Molecular biology, Oncogene, Cell cycle, Estrogen receptor, Cell growth, Nuclear receptor, Nuclear protein, Cancer cell, Biology
Related Organizations
31 references, page 1 of 3

Siegel, R, Ward, E, Brawley, O, Jemal, A. Global Cancer Statistics, 2011 The impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin. 2011; 61: 212-236 [PubMed]

Kawai, H, Ishii, A, Washiya, K, Konno, T, Kon, H, Yamaya, C, Ono, I, Minamiya, Y, Ogawa, J. Estrogen receptor α and β are prognostic factors in non-small cell lung cancer. Clin Cancer Res. 2005; 11: 5084-5089 [PubMed]

Schwartz, AG, Prysak, GM, Murphy, V, Lonardo, F, Pass, H, Schwartz, J, Brooks, S. Nuclear estrogen receptor β in lung cancer: expression and survival differences by sex. Clin Cancer Res. 2005; 11: 7280-7287 [PubMed]

Siegfried, JM, Hershberger, PA, Stabile, LP. Estrogen receptor signaling in lung cancer. Semin Oncol. 2005; 36: 524-534 [OpenAIRE] [PubMed]

Mollerup, S, Jørgensen, K, Berge, G, Haugen, A. Expression of estrogen receptors α and β in human lung tissue and cell lines. Lung Cancer. 2002; 37: 153-159 [OpenAIRE] [PubMed]

Omoto, Y, Kobayashi, Y, Nishida, K, Tsuchiya, E, Eguchi, H, Nakagawa, K, Ishikawa, Y, Yamori, T, Iwase, H, Fujii, Y, Warner, M, Gustafsson, JA, Hayashi, S. Expression, function, and clinical implications of the estrogen receptor β in human lung cancers. Biochem Biophys Res Commun. 2001; 285: 340-347 [PubMed]

Patrone, C, Cassel, T, Pettersscon, K, Piao, Y, Piao, Y, Cheng, G, Ciana, P, Maggi, A, Warner, M, Gustafsson, J, Nord, M. Regulation of postnatal lung development and homeostasis by estrogen receptor β. Mol Cell Biol. 2003; 23: 8542-8552 [OpenAIRE] [PubMed]

Niikawa, H, Suzuki, T, Miki, Y, Suzuki, S, Nagasaki, S, Akahira, J, Honma, S, Evans, DB, Hayashi, S, Kondo, T, Sasano, H. Intratumoral estrogens and estrogen receptors in human non small cell lung carcinoma. Clin Cancer Res. 2008; 14: 4417-4426 [OpenAIRE] [PubMed]

Mah, V, Seligson, D, Li, A, Marquez, D, Wistuba, I, Elshimali, Y, Fishbein, M, Chia, D, Pietras, R, Goodglick, L. Aromatase expression predicts survival in women with early-stage non-small cell lung cancer. Cancer Res. 2007; 21: 10484-10490 [OpenAIRE] [PubMed]

Weinberg, O, Marquez-Garban, D, Fishbein, M, Goodglick, L, Garban, H, Dubinett, S, Pietras, R. Aromatase inhibitors in human lung cancer therapy. Cancer Res. 2005; 24: 11287-11291 [PubMed]

Stabile, L, Gaither Davis, A, Gubish, C, Hopkins, T, Luketich, J, Christie, N, Finkelstein, S, Siegfried, J. Human non-small cell lung tumors and cells derived from normal lung express both estrogen receptor α and β and show biological responses to estrogen. Cancer Res. 2002; 62: 2141-2150 [PubMed]

Chang, C, Kokontis, J, Liao, ST. Molecular cloning of human and rat complementary DNA encoding androgen receptors. Science. 1988; 240: 324-326 [OpenAIRE] [PubMed]

Evans, RM. The steroid and thyroid hormone receptor superfamily. Science. 1988; 240: 889-895 [OpenAIRE] [PubMed]

Beato, M. Gene regulation by steroid hormones. Cell. 1989; 56: 335-344 [OpenAIRE] [PubMed]

Wang, LH, Tsai, SY, Cook, RG, Beattie, WG, Tsai, MJ, O'Malley, BW. Coup transcription factor is a member of the steroid receptor superfamily. Nature. 1989; 340: 163-166 [OpenAIRE] [PubMed]

31 references, page 1 of 3
Abstract
The possible involvement of estrogen receptors (ERs) and testicular orphan nuclear receptors (TRs) in human non- small cell lung carcinoma (NSCLC) has been suggested, but their precise roles and their relationship remain largely unknown. This study aimed to investigate whether TR4-associated protein 16 (TRA16) regulates the ERβ and TR2 pathways and could be a potential target in NSCLC. We used tissue microarrays including NSCLC tissues (n=154) and negative controls (n=14) to examine the expression of TRA16 and ERβ, and in vitro reporter gene assays, the mammalian two-hybrid method and immunoprecipitation in Cos-1 cells to investigate the relation- ships among TR...
Subjects
free text keywords: Articles, ERβ, testicular orphan nuclear receptor 2, TR4-associated protein 16, non-small cell lung cancer, Cancer Research, Oncology, General Medicine, Estrogen receptor beta, Molecular biology, Oncogene, Cell cycle, Estrogen receptor, Cell growth, Nuclear receptor, Nuclear protein, Cancer cell, Biology
Related Organizations
31 references, page 1 of 3

Siegel, R, Ward, E, Brawley, O, Jemal, A. Global Cancer Statistics, 2011 The impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin. 2011; 61: 212-236 [PubMed]

Kawai, H, Ishii, A, Washiya, K, Konno, T, Kon, H, Yamaya, C, Ono, I, Minamiya, Y, Ogawa, J. Estrogen receptor α and β are prognostic factors in non-small cell lung cancer. Clin Cancer Res. 2005; 11: 5084-5089 [PubMed]

Schwartz, AG, Prysak, GM, Murphy, V, Lonardo, F, Pass, H, Schwartz, J, Brooks, S. Nuclear estrogen receptor β in lung cancer: expression and survival differences by sex. Clin Cancer Res. 2005; 11: 7280-7287 [PubMed]

Siegfried, JM, Hershberger, PA, Stabile, LP. Estrogen receptor signaling in lung cancer. Semin Oncol. 2005; 36: 524-534 [OpenAIRE] [PubMed]

Mollerup, S, Jørgensen, K, Berge, G, Haugen, A. Expression of estrogen receptors α and β in human lung tissue and cell lines. Lung Cancer. 2002; 37: 153-159 [OpenAIRE] [PubMed]

Omoto, Y, Kobayashi, Y, Nishida, K, Tsuchiya, E, Eguchi, H, Nakagawa, K, Ishikawa, Y, Yamori, T, Iwase, H, Fujii, Y, Warner, M, Gustafsson, JA, Hayashi, S. Expression, function, and clinical implications of the estrogen receptor β in human lung cancers. Biochem Biophys Res Commun. 2001; 285: 340-347 [PubMed]

Patrone, C, Cassel, T, Pettersscon, K, Piao, Y, Piao, Y, Cheng, G, Ciana, P, Maggi, A, Warner, M, Gustafsson, J, Nord, M. Regulation of postnatal lung development and homeostasis by estrogen receptor β. Mol Cell Biol. 2003; 23: 8542-8552 [OpenAIRE] [PubMed]

Niikawa, H, Suzuki, T, Miki, Y, Suzuki, S, Nagasaki, S, Akahira, J, Honma, S, Evans, DB, Hayashi, S, Kondo, T, Sasano, H. Intratumoral estrogens and estrogen receptors in human non small cell lung carcinoma. Clin Cancer Res. 2008; 14: 4417-4426 [OpenAIRE] [PubMed]

Mah, V, Seligson, D, Li, A, Marquez, D, Wistuba, I, Elshimali, Y, Fishbein, M, Chia, D, Pietras, R, Goodglick, L. Aromatase expression predicts survival in women with early-stage non-small cell lung cancer. Cancer Res. 2007; 21: 10484-10490 [OpenAIRE] [PubMed]

Weinberg, O, Marquez-Garban, D, Fishbein, M, Goodglick, L, Garban, H, Dubinett, S, Pietras, R. Aromatase inhibitors in human lung cancer therapy. Cancer Res. 2005; 24: 11287-11291 [PubMed]

Stabile, L, Gaither Davis, A, Gubish, C, Hopkins, T, Luketich, J, Christie, N, Finkelstein, S, Siegfried, J. Human non-small cell lung tumors and cells derived from normal lung express both estrogen receptor α and β and show biological responses to estrogen. Cancer Res. 2002; 62: 2141-2150 [PubMed]

Chang, C, Kokontis, J, Liao, ST. Molecular cloning of human and rat complementary DNA encoding androgen receptors. Science. 1988; 240: 324-326 [OpenAIRE] [PubMed]

Evans, RM. The steroid and thyroid hormone receptor superfamily. Science. 1988; 240: 889-895 [OpenAIRE] [PubMed]

Beato, M. Gene regulation by steroid hormones. Cell. 1989; 56: 335-344 [OpenAIRE] [PubMed]

Wang, LH, Tsai, SY, Cook, RG, Beattie, WG, Tsai, MJ, O'Malley, BW. Coup transcription factor is a member of the steroid receptor superfamily. Nature. 1989; 340: 163-166 [OpenAIRE] [PubMed]

31 references, page 1 of 3
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publication . Article . 2012

Testicular orphan nuclear receptor 4-associated protein 16 promotes non-small cell lung carcinoma by activating estrogen receptor β and blocking testicular orphan nuclear receptor 2.

FANG FANG; QINGFENG ZHENG; JIANZHI ZHANG; BIN DONG; SAINAN ZHU; XIAOYUN HUANG; YANG WANG; BINGTIAN ZHAO; SHAOLEI LI; HONGCHAO XIONG; ...