publication . Other literature type . Article . 2015

Structural Domains Underlying the Activation of Acid-sensing Ion Channel 2a

Laura-Nadine Schuhmacher; Shyam Srivats; Ewan St. John Smith;
Open Access English
  • Published: 12 Jan 2015
  • Publisher: The American Society for Pharmacology and Experimental Therapeutics
Abstract
The acid-sensing ion channels (ASICs) are a family of ion channels expressed throughout the mammalian nervous system. The principal activator of ASICs is extracellular protons, and ASICs have been demonstrated to play a significant role in many physiologic and pathophysiologic processes, including synaptic transmission, nociception, and fear. However, not all ASICs are proton-sensitive: ASIC2a is activated by acid, whereas its splice variant ASIC2b is not. We made a series of chimeric ASIC2 proteins, and using whole-cell electrophysiology we have identified the minimal region of the ASIC2a extracellular domain that is required for ASIC2 proton activation: the fi...
Subjects
free text keywords: Articles, Molecular Medicine, Pharmacology, Extracellular, Alternative splicing, Biochemistry, Ion channel, Activator (genetics), Acid-sensing ion channel, Transmembrane domain, Biology, Electrophysiology, Patch clamp
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Other literature type . Article . 2015

Structural Domains Underlying the Activation of Acid-sensing Ion Channel 2a

Laura-Nadine Schuhmacher; Shyam Srivats; Ewan St. John Smith;