publication . Article . Other literature type . 2011

helicobacter pylori vaca induces programmed necrosis in gastric epithelial cells

Radin, Jana N.; González-Rivera, Christian; Ivie, Susan E.; McClain, Mark S.; Cover, Timothy L.;
Open Access
  • Published: 01 Jul 2011 Journal: Infection and Immunity, volume 79, pages 2,535-2,543 (issn: 0019-9567, eissn: 1098-5522, Copyright policy)
  • Publisher: American Society for Microbiology
Abstract
<jats:title>ABSTRACT</jats:title><jats:p><jats:named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">Helicobacter pylori</jats:named-content>is a Gram-negative bacterium that colonizes the human stomach and contributes to the development of peptic ulcer disease and gastric cancer. The secreted pore-forming toxin VacA is one of the major virulence factors of<jats:named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">H. pylori</jats:named-content>. In the current study, we show that AZ-521 human gastric epithelial cells are highly susceptible to VacA-induced cel...
Subjects
Medical Subject Headings: digestive system diseases
free text keywords: Immunology, Microbiology, Parasitology, Infectious Diseases, Gastric mucosa, medicine.anatomical_structure, medicine, Poly ADP ribose polymerase, Gastritis, medicine.symptom, Proinflammatory cytokine, Necrosis, Helicobacter pylori, biology.organism_classification, biology, Programmed cell death, Caspase, biology.protein, Molecular Pathogenesis
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publication . Article . Other literature type . 2011

helicobacter pylori vaca induces programmed necrosis in gastric epithelial cells

Radin, Jana N.; González-Rivera, Christian; Ivie, Susan E.; McClain, Mark S.; Cover, Timothy L.;