publication . Other literature type . Article . 2012

Insights into the mechanism of proton transport in cytochrome c oxidase.

Takefumi Yamashita; Gregory A. Voth;
Open Access English
  • Published: 06 Jan 2012
Abstract
Cytochrome c oxidase (CcO), known as complex IV of the electron transport chain, plays several important roles in aerobic cellular respiration. Electrons transferred from cytochrome c to CcO’s catalytic site reduce molecular oxygen and produce a water molecule. These electron transfers also drive active proton pumping from the matrix (N-side) to intermembrane region (P-side) in mitochondria; the resultant proton gradient activates the ATP synthase to produce ATP from ADP. Although the existence of the coupling between the electron transfer and the proton transport (PT) is established experimentally, its mechanism is not yet fully understood at the molecular leve...
Subjects
Medical Subject Headings: macromolecular substances
free text keywords: Article, Colloid and Surface Chemistry, Biochemistry, General Chemistry, Catalysis, ATP synthase, biology.protein, biology, Proton transport, Electron transport chain, Cytochrome C1, Electrochemical gradient, Cytochrome c oxidase, Stereochemistry, Chemistry, Biophysics, Electron Transport Complex IV, Cytochrome c, Inorganic chemistry
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Other literature type . Article . 2012

Insights into the mechanism of proton transport in cytochrome c oxidase.

Takefumi Yamashita; Gregory A. Voth;