Determinants of HMGB Proteins Required To Promote RAG1/2-Recombination Signal Sequence Complex Assembly and Catalysis during V(D)J Recombination

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Dai, Yan; Wong, Ben; Yen, Yi-Meng; Oettinger, Marjorie A.; Kwon, Jongbum; Johnson, Reid C.;

Efficient assembly of RAG1/2-recombination signal sequence (RSS) DNA complexes that are competent for V(D)J cleavage requires the presence of the nonspecific DNA binding and bending protein HMGB1 or HMGB2. We find that either of the two minimal DNA binding domains of HM... View more
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