publication . Article . 2016

Sulforaphane protects against acrolein-induced oxidative stress and inflammatory responses: modulation of Nrf-2 and COX-2 expression.

Qin, Wang-Sen; Deng, Yu-Hui; Cui, Fa-Cai;
Open Access
  • Published: 01 Jul 2016 Journal: Archives of Medical Science, volume 4, pages 871-880 (issn: 1734-1922, Copyright policy)
  • Publisher: Termedia Sp. z.o.o.
Abstract
Introduction Acrolein (2-propenal) is a reactive α, β-unsaturated aldehyde which causes a health hazard to humans. The present study focused on determining the protection offered by sulforaphane against acrolein-induced damage in peripheral blood mononuclear cells (PBMC). Material and methods Acrolein-induced oxidative stress was determined through evaluating the levels of reactive oxygen species, protein carbonyl and sulfhydryl content, thiobarbituric acid reactive species, total oxidant status and antioxidant status (total antioxidant capacity, glutathione, superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase activity). Also, Nrf-2...
Subjects
free text keywords: Inflammation, medicine.symptom, medicine, Peripheral blood mononuclear cell, Oxidative stress, medicine.disease_cause, Sulforaphane, chemistry.chemical_compound, chemistry, Internal medicine, medicine.medical_specialty, Immunology, Health hazard, Cardiology, Acrolein, business.industry, business, Cancer research, Basic Research
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publication . Article . 2016

Sulforaphane protects against acrolein-induced oxidative stress and inflammatory responses: modulation of Nrf-2 and COX-2 expression.

Qin, Wang-Sen; Deng, Yu-Hui; Cui, Fa-Cai;