The Tubulin-Binding Agent Combretastatin A-4-Phosphate Arrests Endothelial Cells in Mitosis and Induces Mitotic Cell Death

Other literature type English OPEN
Kanthou, Chryso; Greco, Olga; Stratford, Anna; Cook, Ian; Knight, Richard; Benzakour, Omar; Tozer, Gillian;
  • Publisher: American Society for Investigative Pathology
  • Related identifiers: pmc: PMC3118836
  • Subject: Regular Articles

The tubulin-binding agent combretastatin A-4-phosphate (CA-4-P), rapidly disrupts the vascular network of tumors leading to secondary tumor cell death. In vitro, CA-4-P destabilizes microtubules and causes endothelial cell death. In this study we analyze the mechanisms ... View more
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