publication . Article . 2018

Evaluation of MAGE-1 and MAGE-3 as tumour-specific markers to detect blood dissemination of hepatocellular carcinoma cells

Mou D-C; Cai S-L; Peng J-R; Wang Y; Chen H-S; Pang X-W; Leng X-S; Chen W-F;
Open Access English
  • Published: 13 Nov 2018 Journal: British Journal of Cancer, volume 86, issue 1, pages 110-116 (issn: 0007-0920, eissn: 1532-1827, Copyright policy)
  • Publisher: Nature Publishing Group
Abstract
The members of MAGE gene family are highly expressed in human hepatocellular carcinoma (HCC). In the present study, we tested the tumour-specific MAGE-1 and MAGE-3 transcripts in the peripheral blood of HCC patients by nested RT–PCR to detect the circulating tumour cells and evaluate their potential clinical implication. Of 30 HCC patients, the positive rate of MAGE-1 and MAGE-3 transcripts was 43.3% (13 out of 30) and 33.3% (10 out of 30) in PBMC samples, whilst the positive rate was 70% (21 out of 30) and 53.3% (16 out of 30) in the resected HCC tissue samples, respectively. The positivity for at least one MAGE gene transcript was 63.3% (19 out of 30) in PBMC ...
Subjects
Medical Subject Headings: neoplasmsendocrine system
free text keywords: Molecular and Cellular Pathology, circulating tumour cells, hepatocellular carcinoma, MAGE transcripts, nested polymerase chain reaction, tumour-specific marker, Cancer Research, Oncology, Gene transcript, Messenger RNA, Polymerase chain reaction, law.invention, law, medicine.disease, medicine, business.industry, business, Peripheral blood mononuclear cell, Immunology, Nucleotidyltransferase, Metastasis, Pathology, medicine.medical_specialty, Cancer
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publication . Article . 2018

Evaluation of MAGE-1 and MAGE-3 as tumour-specific markers to detect blood dissemination of hepatocellular carcinoma cells

Mou D-C; Cai S-L; Peng J-R; Wang Y; Chen H-S; Pang X-W; Leng X-S; Chen W-F;