Further studies at neuropeptide S position 5: discovery of novel neuropeptide S receptor antagonists

Other literature type English OPEN
Guerrini, Remo; Camarda, Valeria; Trapella, Claudio; Calo’, Girolamo; Rizzi, Anna; Ruzza, Chiara; Fiorini, Stella; Marzola, Erika; Reinscheid, Rainer K.; Regoli, Domenico; Salvadori, Severo;
  • Identifiers: doi: 10.1021/jm900604g, pmc: PMC2732566
  • Subject: Article
    mesheuropmc: respiratory system | inorganic chemicals | health care economics and organizations | technology, industry, and agriculture

Neuropeptide S (NPS) regulates various biological functions by activating the NPS receptor (NPSR). Previous studies demonstrated that the substitution of Gly5 with D-amino acids generates NPSR antagonists. Eleven [D-Xaa5]NPS derivatives were synthesized and pharmacologi... View more
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