Cyanidin 3-O-Glucoside Reduces Helicobacter pylori VacA-Induced Cell Death of Gastric KATO III Cells through Inhibition of the SecA Pathway

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Kim, Sa-Hyun; Woo, Hyunjun; Park, Min; Rhee, Ki-Jong; Moon, Cheol; Lee, Dongsup; Seo, Woo Duck; Kim, Jong Bae;
  • Publisher: Ivyspring International Publisher
  • Journal: International Journal of Medical Sciences,volume 11,issue 7,pages742-747 (eissn: 1449-1907)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC4045794, doi: 10.7150/ijms.7167
  • Subject: Short Research Communication | cyanidin 3-O-glucoside | VacA secretion | H. pylori
    mesheuropmc: bacteria | bacterial infections and mycoses | digestive system diseases

Two key virulence factors of Helicobacter pylori are the secreted virulent proteins of vacuolating toxin A (VacA) and cytotoxin associated protein A (CagA) which lead to damages of gastric epithelial cells. We previously identified that the cyanidin 3-O-glucoside (C3G) ... View more
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