publication . Article . Other literature type . 2011

Functional Interaction between Trace Amine-Associated Receptor 1 and Dopamine D2 Receptor

Bernard Masri; Raul Gainetdinov;
Open Access
  • Published: 19 Aug 2011 Journal: Molecular Pharmacology, volume 80, pages 416-425 (issn: 0026-895X, eissn: 1521-0111, Copyright policy)
  • Publisher: American Society for Pharmacology & Experimental Therapeutics (ASPET)
  • Country: France
Abstract
The ability of dopamine receptors to interact with other receptor subtypes may provide mechanisms for modulating dopamine-related functions and behaviors. In particular, there is evidence suggesting that the trace amine-associated receptor 1 (TAAR1) affects the dopaminergic system by regulating the firing rate of dopaminergic neurons or by altering dopamine D2 receptor (D2R) responsiveness to ligands. TAAR1 is a Gαs protein-coupled receptor that is activated by biogenic amines, “trace amines,” such as β-phenylethylamine (β-PEA) and tyramine that are normally found at low concentrations in the mammalian brain. In the present study, we investigated the biochemical...
Subjects
free text keywords: Molecular Medicine, Pharmacology, [SDV]Life Sciences [q-bio], [SDV.BC]Life Sciences [q-bio]/Cellular Biology, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, Articles
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