publication . Other literature type . Article . 2013

Netrin-1 Overexpression Promotes White Matter Repairing and Remodeling after Focal Cerebral Ischemia in Mice:

Xiaosong He; Yaning Li; Haiyan Lu; Zhijun Zhang; Yongting Wang; Guo-Yuan Yang;
Open Access English
  • Published: 21 Aug 2013
  • Publisher: Nature Publishing Group
Abstract
Damage of oligodendrocytes after ischemia has negative impact on white matter integrity and neuronal function. In this work, we explore whether Netrin-1 (NT-1) overexpression facilitates white matter repairing and remodeling. Adult CD-1 mice received stereotactic injection of adeno-associated virus carrying NT-1 gene (AAV-NT-1). One week after gene transfer, mice underwent 60 minutes of middle cerebral artery occlusion. The effect of NT-1 on neural function was evaluated by neurobehavioral tests. Proliferated oligodendrocyte progenitor cells (OPCs), newly matured oligodendrocytes, and remyelination were semi-quantified by immunohistochemistry. The role of NT-1 i...
Subjects
Medical Subject Headings: nervous system
free text keywords: Original Article, Neurology, Clinical Neurology, Cardiology and Cardiovascular Medicine, White matter, medicine.anatomical_structure, medicine, Biology, Brain ischemia, medicine.disease, Stereotactic injection, Remyelination, Anesthesia, Immunology, Nerve growth factor, Pathology, medicine.medical_specialty, Ischemia, Netrin, Deleted in Colorectal Cancer
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publication . Other literature type . Article . 2013

Netrin-1 Overexpression Promotes White Matter Repairing and Remodeling after Focal Cerebral Ischemia in Mice:

Xiaosong He; Yaning Li; Haiyan Lu; Zhijun Zhang; Yongting Wang; Guo-Yuan Yang;