publication . Article . 2014

Evaluation of adenosine deaminase (ADA) isoenzymes activity and tumor necrosis factor-α (TNFα) concentration in chronic heart failure

Khodadadi I; Ms, Vahedi; Abdi M; Daneshkhah N; Rahbari R; Shaho Menbari; Ahmadi D; Ahmadi A; Lahoorpour F; Ms, Hakhamaneshi; ...
Open Access English
  • Published: 01 Feb 2014 Journal: EXCLI Journal, volume 13, pages 58-66 (eissn: 1611-2156, Copyright policy)
  • Publisher: Leibniz Research Centre for Working Environment and Human Factors
Abstract
Introduction: Chronic heart failure (CHF) has recently been considered as an inflammatory disease. Enhanced production of tumor necrosis factor-α (TNFα) in CHF patients has been proved. To compensate deleterious effects of TNα, the concentration of adenosine is increased in CHF. However, concurrent determination of serum TNFα and enzymatic activities of ADA and its ADA1 and ADA2 isoenzymes, as the main regulators of adenosine concentration, has not yet been carried out. Materials and Methods: Blood samples were collected from 52 CHF patients and 55 healthy controls. Laboratory routine tests were performed, and after determining the concentration of TNFα, total A...
Subjects
free text keywords: Original Article, Adenosine deaminase, heart failure, isoenzymes, tumor necrosis factor-alpha
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publication . Article . 2014

Evaluation of adenosine deaminase (ADA) isoenzymes activity and tumor necrosis factor-α (TNFα) concentration in chronic heart failure

Khodadadi I; Ms, Vahedi; Abdi M; Daneshkhah N; Rahbari R; Shaho Menbari; Ahmadi D; Ahmadi A; Lahoorpour F; Ms, Hakhamaneshi; ...