c9,t11-Conjugated linoleic acid ameliorates steatosis by modulating mitochondrial uncoupling and Nrf2 pathway[S]

Other literature type English OPEN
Mollica, Maria Pina; Trinchese, Giovanna; Cavaliere, Gina; De Filippo, Chiara; Cocca, Ennio; Gaita, Marcello; Della-Gatta, Antonio; Marano, Angela; Mazzarella, Giuseppe; Bergamo, Paolo;
  • Publisher: The American Society for Biochemistry and Molecular Biology
  • Related identifiers: pmc: PMC3995462, doi: 10.1194/jlr.M044032
  • Subject: Research Articles
    mesheuropmc: food and beverages | lipids (amino acids, peptides, and proteins) | integumentary system

Oxidative stress, hepatic steatosis, and mitochondrial dysfunction are key pathophysiological features of nonalcoholic fatty liver disease. A conjugated linoleic acid (CLA) mixture of cis9,trans11 (9,11-CLA) and trans10,cis12 (10,12-CLA) isomers enhanced the antioxidant... View more
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