publication . Article . Other literature type . 2012

Taok2and ethanol behaviors

Kapfhamer D.; Taylor S.; Zou M. E.; Lim J. P.; Kharazia V.; Heberlein U.;
Open Access
  • Published: 31 Aug 2012 Journal: Genes, Brain and Behavior, volume 12, pages 87-97 (issn: 1601-1848, Copyright policy)
  • Publisher: Wiley
Abstract
Despite recent advances in the understanding of ethanol’s biological action, many of the molecular targets of ethanol and mechanisms behind ethanol’s effect on behavior remain poorly understood. In an effort to identify novel genes, the products of which regulate behavioral responses to ethanol, we recently identified a mutation in the dtao gene that confers resistance to the locomotor stimulating effect of ethanol in Drosophila. dtao encodes a member of the Ste20 family of serine/threonine kinases implicated in MAP kinase signaling pathways. In the present study, we report that conditional ablation of the mouse dtao homolog, Taok2, constitutively and specifical...
Subjects
free text keywords: Genetics, Behavioral Neuroscience, Neurology, Candidate gene, MAP kinase kinase kinase, Mutation, medicine.disease_cause, medicine, Gene, Serine, Biology, Mitogen-activated protein kinase, biology.protein, Protein-Serine-Threonine Kinases, Kinase, Article
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