publication . Other literature type . Article . 2014

Zonula Occludens-1, Occludin and E-cadherin Expression and Organization in Salivary Glands with Sjögren’s Syndrome

Rachel E. Mellas; Noel J. Leigh; Joel W. Nelson; Andrew D. McCall; Olga J. Baker;
  • Published: 23 Sep 2014
  • Publisher: SAGE Publications
Abstract
Sjögren’s syndrome (SS) is a chronic inflammatory autoimmune disorder that causes secretory dysfunction of the salivary glands leading to dry mouth. Previous studies reported that tight junction (TJ) proteins are down-regulated and lose polarity in human minor salivary glands with SS, suggesting that TJ structure is compromised in SS patients. In this paper, we utilized the NOD/ShiLtJ mouse with the main goal of evaluating this model for future TJ research. We found that the organization of apical proteins in areas proximal and distal to lymphocytic infiltration remained intact in mouse and human salivary glands with SS. These areas looked comparable to control ...
Subjects
free text keywords: Articles, Anatomy, Histology, Regulation of gene expression, Gene expression, Nod, Cadherin, Submandibular gland, medicine.anatomical_structure, medicine, Epithelium, Pathology, medicine.medical_specialty, Tight junction, Occludin, Endocrinology, Internal medicine, Biology
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Other literature type . Article . 2014

Zonula Occludens-1, Occludin and E-cadherin Expression and Organization in Salivary Glands with Sjögren’s Syndrome

Rachel E. Mellas; Noel J. Leigh; Joel W. Nelson; Andrew D. McCall; Olga J. Baker;