publication . Article . 2017

Dynamics and function of CXCR4 in formation of the granule cell layer during hippocampal development.

Mimura-Yamamoto, Yuka; Shinohara, Hiroshi; Kashiwagi, Taichi; Sato, Toru; Shioda, Seiji; Seki, Tatsunori;
Open Access
  • Published: 17 Jul 2017 Journal: Scientific Reports, volume 7 (eissn: 2045-2322, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
In the developing hippocampus, granule cell progenitors (GCPs) arising in the ventricular zone (VZ) migrate to the subpial region, and form the granule cell layer (GCL) of the dentate gyrus (DG). To understand the mechanism of GCL formation, we investigated the dynamics and function of CXCR4 which is expressed by the GCPs and is a receptor of the CXCL12 chemokine secreted by cells surrounding the DG. In the VZ, CXCR4 was expressed on the plasma membrane of the GCPs. During their migration and in the DG, CXCR4 was internalized and accumulated as puncta close to the centrosomes, Golgi apparatus, and lysosomes. Phosphatase analysis suggested that both phosphorylate...
Subjects
free text keywords: Multidisciplinary, Golgi apparatus, symbols.namesake, symbols, Cellular differentiation, Neural stem cell, Cell biology, Dentate gyrus, Biology, Intracellular, Immunology, Granule cell, medicine.anatomical_structure, medicine, Hippocampal formation, Cell membrane, Article
62 references, page 1 of 5

Altman, J, Das, GD. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J. Comp. Neurol.. 1965; 124: 319-35 [OpenAIRE] [PubMed] [DOI]

Seki, T, Namba, T, Mochizuki, H, Onodera, M. Clustering, migration, and neurite formation of neural precursor cells in the adult rat hippocampus. J. Comp. Neurol.. 2007; 502: 275-290 [OpenAIRE] [PubMed] [DOI]

Treves, A, Tashiro, A, Witter, MP, Moser, EI. What is the mammalian dentate gyrus good for?. Neuroscience. 2008; 154: 1155-1172 [OpenAIRE] [PubMed] [DOI]

4.Kempermann, G. Adult neurogenesis 2: stem cells and neuronal development in the adult brain. (Oxford University Press, 2011).

Snyder, JS, Cameron, HA. Could adult hippocampal neurogenesis be relevant for human behavior?. Behav. Brain Res.. 2012; 227: 384-390 [OpenAIRE] [PubMed] [DOI]

Kempermann, G, Song, H, Gage, FH. Neurogenesis in the Adult Hippocampus. Cold Spring Harb. Perspect. Biol.. 2015; 7: a018812 [OpenAIRE] [PubMed] [DOI]

Drew, LJ, Fusi, S, Hen, R. Adult neurogenesis in the mammalian hippocampus: Why the dentate gyrus?. Learn. Mem.. 2013; 20: 710-729 [OpenAIRE] [PubMed] [DOI]

Abrous, DN, Wojtowicz, JM. Interaction between Neurogenesis and Hippocampal Memory System: New Vistas. Cold Spring Harb. Perspect. Biol.. 2015; 7: a018952 [OpenAIRE] [PubMed] [DOI]

Georg Kuhn, H, Blomgren, K. Developmental dysregulation of adult neurogenesis. Eur. J. Neurosci.. 2011; 33: 1115-22 [OpenAIRE] [PubMed] [DOI]

Eisch, AJ, Petrik, D. Depression and Hippocampal Neurogenesis: A Road to Remission?. Science (80-.). 2012; 338: 72-75 [OpenAIRE] [DOI]

Altman, J, Bayer, SA. Migration and distribution of two populations of hippocampal granule cell precursors during the perinatal and postnatal periods. J. Comp. Neurol.. 1990; 301: 365-81 [OpenAIRE] [PubMed] [DOI]

12.Seki, T. From embryonic to adult neurogenesis in the dentate gyrus in Neurogenesis in the Adult Brain I (eds. Seki, T., Sawamoto, K., Parent, J. M. & Alvarez-Buylla, A.) 193–216 (Springer, 2011).

Seki, T. Distinctive population of Gfap-expressing neural progenitors arising around the dentate notch migrate and form the granule cell layer in the developing hippocampus. J. Comp. Neurol.. 2014; 522: 261-283 [OpenAIRE] [PubMed] [DOI]

Li, G, Kataoka, H, Coughlin, SR, Pleasure, SJ. Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling. Development. 2009; 136: 327-335 [OpenAIRE] [PubMed] [DOI]

Li, G, Pleasure, SJ. The development of hippocampal cellular assemblies. Wiley Interdiscip. Rev. Dev. Biol.. 2014; 3: 165-177 [OpenAIRE] [PubMed] [DOI]

62 references, page 1 of 5
Abstract
In the developing hippocampus, granule cell progenitors (GCPs) arising in the ventricular zone (VZ) migrate to the subpial region, and form the granule cell layer (GCL) of the dentate gyrus (DG). To understand the mechanism of GCL formation, we investigated the dynamics and function of CXCR4 which is expressed by the GCPs and is a receptor of the CXCL12 chemokine secreted by cells surrounding the DG. In the VZ, CXCR4 was expressed on the plasma membrane of the GCPs. During their migration and in the DG, CXCR4 was internalized and accumulated as puncta close to the centrosomes, Golgi apparatus, and lysosomes. Phosphatase analysis suggested that both phosphorylate...
Subjects
free text keywords: Multidisciplinary, Golgi apparatus, symbols.namesake, symbols, Cellular differentiation, Neural stem cell, Cell biology, Dentate gyrus, Biology, Intracellular, Immunology, Granule cell, medicine.anatomical_structure, medicine, Hippocampal formation, Cell membrane, Article
62 references, page 1 of 5

Altman, J, Das, GD. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J. Comp. Neurol.. 1965; 124: 319-35 [OpenAIRE] [PubMed] [DOI]

Seki, T, Namba, T, Mochizuki, H, Onodera, M. Clustering, migration, and neurite formation of neural precursor cells in the adult rat hippocampus. J. Comp. Neurol.. 2007; 502: 275-290 [OpenAIRE] [PubMed] [DOI]

Treves, A, Tashiro, A, Witter, MP, Moser, EI. What is the mammalian dentate gyrus good for?. Neuroscience. 2008; 154: 1155-1172 [OpenAIRE] [PubMed] [DOI]

4.Kempermann, G. Adult neurogenesis 2: stem cells and neuronal development in the adult brain. (Oxford University Press, 2011).

Snyder, JS, Cameron, HA. Could adult hippocampal neurogenesis be relevant for human behavior?. Behav. Brain Res.. 2012; 227: 384-390 [OpenAIRE] [PubMed] [DOI]

Kempermann, G, Song, H, Gage, FH. Neurogenesis in the Adult Hippocampus. Cold Spring Harb. Perspect. Biol.. 2015; 7: a018812 [OpenAIRE] [PubMed] [DOI]

Drew, LJ, Fusi, S, Hen, R. Adult neurogenesis in the mammalian hippocampus: Why the dentate gyrus?. Learn. Mem.. 2013; 20: 710-729 [OpenAIRE] [PubMed] [DOI]

Abrous, DN, Wojtowicz, JM. Interaction between Neurogenesis and Hippocampal Memory System: New Vistas. Cold Spring Harb. Perspect. Biol.. 2015; 7: a018952 [OpenAIRE] [PubMed] [DOI]

Georg Kuhn, H, Blomgren, K. Developmental dysregulation of adult neurogenesis. Eur. J. Neurosci.. 2011; 33: 1115-22 [OpenAIRE] [PubMed] [DOI]

Eisch, AJ, Petrik, D. Depression and Hippocampal Neurogenesis: A Road to Remission?. Science (80-.). 2012; 338: 72-75 [OpenAIRE] [DOI]

Altman, J, Bayer, SA. Migration and distribution of two populations of hippocampal granule cell precursors during the perinatal and postnatal periods. J. Comp. Neurol.. 1990; 301: 365-81 [OpenAIRE] [PubMed] [DOI]

12.Seki, T. From embryonic to adult neurogenesis in the dentate gyrus in Neurogenesis in the Adult Brain I (eds. Seki, T., Sawamoto, K., Parent, J. M. & Alvarez-Buylla, A.) 193–216 (Springer, 2011).

Seki, T. Distinctive population of Gfap-expressing neural progenitors arising around the dentate notch migrate and form the granule cell layer in the developing hippocampus. J. Comp. Neurol.. 2014; 522: 261-283 [OpenAIRE] [PubMed] [DOI]

Li, G, Kataoka, H, Coughlin, SR, Pleasure, SJ. Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling. Development. 2009; 136: 327-335 [OpenAIRE] [PubMed] [DOI]

Li, G, Pleasure, SJ. The development of hippocampal cellular assemblies. Wiley Interdiscip. Rev. Dev. Biol.. 2014; 3: 165-177 [OpenAIRE] [PubMed] [DOI]

62 references, page 1 of 5
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publication . Article . 2017

Dynamics and function of CXCR4 in formation of the granule cell layer during hippocampal development.

Mimura-Yamamoto, Yuka; Shinohara, Hiroshi; Kashiwagi, Taichi; Sato, Toru; Shioda, Seiji; Seki, Tatsunori;