Complete differentiation between enkephalinase and angiotensin-converting enzyme inhibition by retro-thiorphan.

Other literature type English OPEN
Roques, B P; Lucas-Soroca, E; Chaillet, P; Costentin, J; Fournié-Zaluski, M C;

Thiorphan, N-[(R,S)-3-mercapto-2-benzylpropanoyl]glycine is a highly potent inhibitor (Ki = 3.5 nM) of "enkephalinase," a metalloendopeptidase cleaving the Gly-Phe bond (positions 3 and 4) of enkephalins in brain tissue. In accordance with this property, thiorphan displ... View more
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