Anti‐inflammaging effects of human alpha‐1 antitrypsin

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Yuan, Ye; DiCiaccio, Benedetto; Li, Ying; Elshikha, Ahmed S.; Titov, Denis; Brenner, Brian; Seifer, Lee; Pan, Hope; Karic, Nurdina; Akbar, Mohammad A.; Lu, Yuanqing; Song, Sihong; Zhou, Lei;
  • Publisher: John Wiley and Sons Inc.
  • Journal: Aging Cell,volume 17,issue 1 (issn: 1474-9718, eissn: 1474-9726)
  • Related identifiers: doi: 10.1111/acel.12694, pmc: PMC5770780
  • Subject: Original Article | inflammaging | Drosophila | NF‐κB | innate immune response | human alpha‐1 antitrypsin | Original Articles | senescence‐associated secretory phenotype

Summary Inflammaging plays an important role in most age‐related diseases. However, the mechanism of inflammaging is largely unknown, and therapeutic control of inflammaging is challenging. Human alpha‐1 antitrypsin (hAAT) has immune‐regulatory, anti‐inflammatory, and c... View more
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