publication . Article . Other literature type . 2009

Anidulafungin Is Fungicidal and Exerts a Variety of Postantifungal Effects against Candida albicans, C. glabrata, C. parapsilosis, and C. krusei isolates

Nguyen, Katherine T.; Ta, Philip; Hoang, Bich Thu; Cheng, Shaoji; Hao, Binghua; Nguyen, M. Hong; Clancy, Cornelius J.;
  • Published: 13 Apr 2009
  • Publisher: American Society for Microbiology
Abstract
<jats:title>ABSTRACT</jats:title> <jats:p>Anidulafungin targets the cell walls of <jats:italic>Candida</jats:italic> species by inhibiting β-1,3-glucan synthase, thereby killing isolates and exerting prolonged postantifungal effects (PAFEs). We performed time-kill and PAFE experiments on <jats:italic>Candida albicans</jats:italic> (<jats:italic>n</jats:italic> = 4), <jats:italic>C. glabrata</jats:italic> (<jats:italic>n</jats:italic> = 3), <jats:italic>C. parapsilosis</jats:italic> (<jats:italic>n</jats:italic> = 3), and <jats:italic>C. krusei</jats:italic> (<jats:italic>n</jats:italic> = 2) isolates and characterized the PAFEs in greater detail. MICs were 0.008...
Subjects
free text keywords: Pharmacology (medical), Pharmacology, Infectious Diseases, Candida albicans, biology.organism_classification, biology, Yeast, Enzyme, chemistry.chemical_classification, chemistry, Fungi imperfecti, Microbiology, Enzyme inhibitor, biology.protein, Anidulafungin, medicine.drug, medicine, Calcofluor-white, Corpus albicans
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