publication . Article . 2017

Microvesicles as Potential Biomarkers for the Identification of Senescence in Human Mesenchymal Stem Cells

Lei, Qian; Liu, Teng; Gao, Fei; Xie, Hui; Sun, Li; Zhao, Aiqi; Ren, Wenxiang; Guo, Hao; Zhang, Liming; Wang, Hongxiang; ...
Open Access English
  • Published: 01 Jul 2017 Journal: Theranostics, volume 7, issue 10, pages 2,673-2,689 (eissn: 1838-7640, Copyright policy)
  • Publisher: Ivyspring International Publisher
Abstract
Senescence in human mesenchymal stem cells (MSCs) not only contributes to organism aging and the development of a variety of diseases but also severely impairs their therapeutic properties as a promising cell therapy. Studies searching for efficient biomarkers that represent cellular senescence have attracted much attention; however, no single marker currently provides an accurate cell-free representation of cellular senescence. Here, we studied characteristics of MSC-derived microvesicles (MSC-MVs) that may reflect the senescence in their parental MSCs. We found that senescent late passage (LP) MSCs secreted higher levels of MSC-MVs with smaller size than did e...
Subjects
free text keywords: senescence, mesenchymal stem cells, microvesicles, biomarker., Research Paper
63 references, page 1 of 5

Friedenstein, AJ, Chailakhjan, RK, Lalykina, KS. The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet. 1970; 3: 393-403 [PubMed]

Karantalis, V, Hare, JM. Use of mesenchymal stem cells for therapy of cardiac disease. Circ Res. 2015; 116: 1413-30 [OpenAIRE] [PubMed]

Pittenger, MF, Mackay, AM, Beck, SC, Jaiswal, RK, Douglas, R, Mosca, JD. Multilineage potential of adult human mesenchymal stem cells. Science. 1999; 284: 143-7 [OpenAIRE] [PubMed]

Jiang, Y, Jahagirdar, BN, Reinhardt, RL, Schwartz, RE, Keene, CD, Ortiz-Gonzalez, XR. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 2002; 418: 41-9 [OpenAIRE] [PubMed]

Krause, DS. Bone marrow-derived cells and stem cells in lung repair. Proc Am Thorac Soc. 2008; 5: 323-7 [OpenAIRE] [PubMed]

Kopen, GC, Prockop, DJ, Phinney, DG. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci U S A. 1999; 96: 10711-6 [OpenAIRE] [PubMed]

Sa da Bandeira, D, Casamitjana, J, Crisan, M. Pericytes, integral components of adult hematopoietic stem cell niches. Pharmacol Ther. 2016

Ansboro, S, Roelofs, AJ, De Bari, C. Mesenchymal stem cells for the management of rheumatoid arthritis: immune modulation, repair or both?. Curr Opin Rheumatol. 2016

Liu, H, Xia, X, Li, B. Mesenchymal stem cell aging: Mechanisms and influences on skeletal and non-skeletal tissues. Exp Biol Med (Maywood). 2015; 240: 1099-106 [OpenAIRE] [PubMed]

Reitinger, S, Schimke, M, Klepsch, S, de Sneeuw, S, Yani, SL, Gassner, R. Systemic impact molds mesenchymal stromal/stem cell aging. Transfus Apher Sci. 2015; 52: 285-9 [PubMed]

Wagner, W, Ho, AD, Zenke, M. Different facets of aging in human mesenchymal stem cells. Tissue Eng Part B Rev. 2010; 16: 445-53 [PubMed]

Matjusaitis, M, Chin, G, Sarnoski, EA, Stolzing, A. Biomarkers to identify and isolate senescent cells. Ageing Res Rev. 2016; 29: 1-12 [PubMed]

Ozcan, S, Alessio, N, Acar, MB, Mert, E, Omerli, F, Peluso, G. Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses. Aging (Albany NY). 2016; 8: 1316-29 [OpenAIRE] [PubMed]

O'Hagan-Wong, K, Nadeau, S, Carrier-Leclerc, A, Apablaza, F, Hamdy, R, Shum-Tim, D. Increased IL-6 secretion by aged human mesenchymal stromal cells disrupts hematopoietic stem and progenitor cells' homeostasis. Oncotarget. 2016; 7: 13285-96 [OpenAIRE] [PubMed]

Severino, V, Alessio, N, Farina, A, Sandomenico, A, Cipollaro, M, Peluso, G. Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells. Cell Death Dis. 2013; 4: e911 [OpenAIRE] [PubMed]

63 references, page 1 of 5
Abstract
Senescence in human mesenchymal stem cells (MSCs) not only contributes to organism aging and the development of a variety of diseases but also severely impairs their therapeutic properties as a promising cell therapy. Studies searching for efficient biomarkers that represent cellular senescence have attracted much attention; however, no single marker currently provides an accurate cell-free representation of cellular senescence. Here, we studied characteristics of MSC-derived microvesicles (MSC-MVs) that may reflect the senescence in their parental MSCs. We found that senescent late passage (LP) MSCs secreted higher levels of MSC-MVs with smaller size than did e...
Subjects
free text keywords: senescence, mesenchymal stem cells, microvesicles, biomarker., Research Paper
63 references, page 1 of 5

Friedenstein, AJ, Chailakhjan, RK, Lalykina, KS. The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet. 1970; 3: 393-403 [PubMed]

Karantalis, V, Hare, JM. Use of mesenchymal stem cells for therapy of cardiac disease. Circ Res. 2015; 116: 1413-30 [OpenAIRE] [PubMed]

Pittenger, MF, Mackay, AM, Beck, SC, Jaiswal, RK, Douglas, R, Mosca, JD. Multilineage potential of adult human mesenchymal stem cells. Science. 1999; 284: 143-7 [OpenAIRE] [PubMed]

Jiang, Y, Jahagirdar, BN, Reinhardt, RL, Schwartz, RE, Keene, CD, Ortiz-Gonzalez, XR. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 2002; 418: 41-9 [OpenAIRE] [PubMed]

Krause, DS. Bone marrow-derived cells and stem cells in lung repair. Proc Am Thorac Soc. 2008; 5: 323-7 [OpenAIRE] [PubMed]

Kopen, GC, Prockop, DJ, Phinney, DG. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci U S A. 1999; 96: 10711-6 [OpenAIRE] [PubMed]

Sa da Bandeira, D, Casamitjana, J, Crisan, M. Pericytes, integral components of adult hematopoietic stem cell niches. Pharmacol Ther. 2016

Ansboro, S, Roelofs, AJ, De Bari, C. Mesenchymal stem cells for the management of rheumatoid arthritis: immune modulation, repair or both?. Curr Opin Rheumatol. 2016

Liu, H, Xia, X, Li, B. Mesenchymal stem cell aging: Mechanisms and influences on skeletal and non-skeletal tissues. Exp Biol Med (Maywood). 2015; 240: 1099-106 [OpenAIRE] [PubMed]

Reitinger, S, Schimke, M, Klepsch, S, de Sneeuw, S, Yani, SL, Gassner, R. Systemic impact molds mesenchymal stromal/stem cell aging. Transfus Apher Sci. 2015; 52: 285-9 [PubMed]

Wagner, W, Ho, AD, Zenke, M. Different facets of aging in human mesenchymal stem cells. Tissue Eng Part B Rev. 2010; 16: 445-53 [PubMed]

Matjusaitis, M, Chin, G, Sarnoski, EA, Stolzing, A. Biomarkers to identify and isolate senescent cells. Ageing Res Rev. 2016; 29: 1-12 [PubMed]

Ozcan, S, Alessio, N, Acar, MB, Mert, E, Omerli, F, Peluso, G. Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses. Aging (Albany NY). 2016; 8: 1316-29 [OpenAIRE] [PubMed]

O'Hagan-Wong, K, Nadeau, S, Carrier-Leclerc, A, Apablaza, F, Hamdy, R, Shum-Tim, D. Increased IL-6 secretion by aged human mesenchymal stromal cells disrupts hematopoietic stem and progenitor cells' homeostasis. Oncotarget. 2016; 7: 13285-96 [OpenAIRE] [PubMed]

Severino, V, Alessio, N, Farina, A, Sandomenico, A, Cipollaro, M, Peluso, G. Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells. Cell Death Dis. 2013; 4: e911 [OpenAIRE] [PubMed]

63 references, page 1 of 5
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