Chloroquine attenuates LPS-mediated macrophage activation through miR-669n-regulated SENP6 protein translation

Other literature type English OPEN
Long, Yupeng; Liu, Xin; Wang, Ning; Zhou, Hong; Zheng, Jiang;
(2015)
  • Publisher: e-Century Publishing Corporation
  • Related identifiers: pmc: PMC4697713
  • Subject: Original Article
    mesheuropmc: lipids (amino acids, peptides, and proteins)

Chloroquine (CQ) has been shown to inhibit Toll-like receptor 4 (TLR4)-mediated monocyte and macrophage activation induced by lipopolysaccharide (LPS). However, the underlying mechanisms have not been completely elucidated. Recently, SUMO-specific protease 6 (SENP6) has... View more
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