Controlled Human Hookworm Infection: Accelerating Human Hookworm Vaccine Development

Article English OPEN
Diemert, David ; Campbell, Doreen ; Brelsford, Jill ; Leasure, Caitlyn ; Li, Guangzhao ; Peng, Jin ; Zumer, Maria ; Younes, Naji ; Bottazzi, Maria Elena ; Mejia, Rojelio ; Pritchard, David I ; Hawdon, John M ; Bethony, Jeffrey M (2018)
  • Publisher: Oxford University Press
  • Journal: Open Forum Infectious Diseases, volume 5, issue 5 (eissn: 2328-8957)
  • Related identifiers: doi: 10.1093/ofid/ofy083, pmc: PMC5952933
  • Subject: Major Article | controlled human hookworm infection | challenge model | current good manufacturing practice | hookworm vaccine | Necator americanus
    mesheuropmc: parasitic diseases

Abstract Background Controlled human hookworm infection (CHHI) is a central component of a proposed hookworm vaccination-challenge model (HVCM) to test the efficacy of candidate vaccines. Critical to CHHI is the manufacture of Necator americanus infective larvae (NaL3) ... View more
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