publication . Article . 2016

Overexpression of N141I PS2 increases γ-secretase activity through up-regulation of Presenilin and Pen-2 in brain mitochondria of NSE/hPS2m transgenic mice

Yun, Woo Bin; Park, Jin Ju; Kim, Ji Eun; Sung, Ji Eun; Lee, Hyun Ah; Lee, Jae Ho; Bae, Chang Jun; Hwang, Dae Youn;
Open Access English
  • Published: 01 Dec 2016 Journal: Laboratory Animal Research (issn: 2233-7660, Copyright policy)
  • Publisher: BMC
Abstract
Abstract Alzheimer’s disease (AD) is known to induce alterations of mitochondrial function such as elevation of oxidative stress and activation of apopotosis. The aim of this study was to investigate the effects of human Presenilin 2 mutant (hPS2m) overexpression on the γ-secretase complex in the mitochondrial fraction. To achieve this, alterations of γ-secretase complex expression and activity were detected in the mitochondrial fraction derived from brains of NSE/hPS2m Tg mice and Non-Tg mice. Herein, the following were observed: i) overexpression of the hPS2m gene significantly up-regulated the deposition of Aβ-42 peptides in the hippocampus and cortex of brai...
Subjects
free text keywords: Alzheimer’s disease, presenilin 2, γ-secretase complex, Aβ-42 peptides, Medicine (General), R5-920, Biology (General), QH301-705.5, Original Article, Alzheimer's disease, Molecular biology, Biology, Activator (genetics), Presenilin, PEN-2, biology.protein, Oxidative stress, medicine.disease_cause, medicine, Genetically modified mouse, Hippocampus, Downregulation and upregulation, Amyloid precursor protein secretase
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publication . Article . 2016

Overexpression of N141I PS2 increases γ-secretase activity through up-regulation of Presenilin and Pen-2 in brain mitochondria of NSE/hPS2m transgenic mice

Yun, Woo Bin; Park, Jin Ju; Kim, Ji Eun; Sung, Ji Eun; Lee, Hyun Ah; Lee, Jae Ho; Bae, Chang Jun; Hwang, Dae Youn;