Do human B-lymphocytes avoid aging until 60 years?

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Knight, Andrea ; Nemec, Pavel ; Bretzova, Sona ; Valkova, Lucie ; Kolmanova, Marketa ; Vytopilova, Renata ; Havelka, Marek ; Vsianska, Pavla ; Rihova, Lucie ; Krejci, Marta ; Piskacek, Martin (2016)
  • Publisher: Impact Journals LLC
  • Journal: Oncotarget, volume 7, issue 28, pages 42,873-42,880 (eissn: 1949-2553)
  • Related identifiers: pmc: PMC5189993, doi: 10.18632/oncotarget.10146
  • Subject: naive B cells | GEP | Gerotarget | aging | B cell | Research Paper: Gerotarget (Focus on Aging) | IL7R

Broad changes in human innate and adaptive immunity are associated with advanced age. The age-related alteration of gene expression was reported for both T and B lymphocytes. We analysed the genome-wide expression profiles (n=20) of naive and whole B cell populations fr... View more
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