publication . Article . Other literature type . 2018

metabolism and growth inhibitory activity of cranberry derived flavonoids in bladder cancer cells

Prasain Jeevan K.; Rajbhandari Rajani; Keeton Adam B.; Piazza Gary A.; Barnes Stephen;
Open Access
  • Published: 13 Nov 2018 Journal: Food & Function, volume 7, pages 4,012-4,019 (issn: 2042-6496, eissn: 2042-650X, Copyright policy)
  • Publisher: Royal Society of Chemistry (RSC)
Abstract
In the present study, anti-proliferative activities of cranberry derived flavonoids and some of their in vivo metabolites were evaluated using a panel of human bladder tumor cell lines (RT4, SCABER, and SW-780) and non-tumorigenic immortalized human uroepithelial cells (SV-HUC). Among the compounds tested, quercetin 3-O-glucoside, isorhamnetin (3′-O-methylquercetin), myricetin and quercetin showed strong concentration-dependent cell growth inhibitory activities in bladder cancer cells with IC50 values in a range of 8–92 μM. Furthermore, isorhamnetin and myricetin had very low inhibitory activity against SV-HUC even at very high concentrations (>200 μM) compared ...
Subjects
Medical Subject Headings: heterocyclic compounds
free text keywords: Food Science, General Medicine, Chemistry, Biochemistry, Quercetin, chemistry.chemical_compound, Cancer cell, Cell growth, Cell culture, Pharmacology, Bladder cancer, medicine.disease, medicine, Hyperoside, Isorhamnetin, Myricetin, Article
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publication . Article . Other literature type . 2018

metabolism and growth inhibitory activity of cranberry derived flavonoids in bladder cancer cells

Prasain Jeevan K.; Rajbhandari Rajani; Keeton Adam B.; Piazza Gary A.; Barnes Stephen;