Biochemical characterization of variants of canine CYP1A1 using heterologous expression

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YU, Hee Jeong ; LEE, Seung Heon ; LEE, Seungwoo ; CHOI, Yu Jung ; OH, Dayoung ; NAM, Ki-Hoan ; YUN, YoungMin ; RYU, Doug-Young (2017)
  • Publisher: The Japanese Society of Veterinary Science
  • Journal: The Journal of Veterinary Medical Science, volume 79, issue 8, pages 1,327-1,334 (issn: 0916-7250, eissn: 1347-7439)
  • Related identifiers: doi: 10.1292/jvms.17-0192, pmc: PMC5573817
  • Subject: heme | enzyme activity | Biochemistry | Full Paper | CYP1A1 | dog | holoenzyme
    mesheuropmc: respiratory system

Cytochrome P450 1A1 (CYP1A1) is a heme-containing mono-oxygenase involved in metabolism of environmental contaminants. Two variants of dog CYP1A1 with a single residue difference were identified and designated Sap1 and Sap2. Compared with Sap1, Sap2 had a Trp50Leu subst... View more
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