publication . Other literature type . 2017

Insulin-like Growth Factor Binding Protein-2 Interactions with Alzheimer's Disease Biomarkers

Lane, Elizabeth M.; Hohman, Timothy J.; Jefferson, Angela L.;
Open Access English
  • Published: 01 Dec 2017
Plasma levels of insulin-like growth factor binding protein-2 (IGFBP-2) have been associated with Alzheimer's disease (AD) and brain atrophy. Some evidence suggests a potential synergistic effect of IGFBP-2 and AD neuropathology on neurodegeneration, while other evidence suggests the effect of IGFBP-2 on neurodegeneration is independent of AD neuropathology. Therefore, the current study investigated the interaction between plasma IGFBP-2 and cerebrospinal fluid (CSF) biomarkers of AD neuropathology on hippocampal volume and cognitive function. AD Neuroimaging Initiative data were accessed (n=354, 75±7 years, 38% female), including plasma IGFBP-2, CSF total tau, ...
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Other literature type . 2017
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