publication . Article . Other literature type . 2009

Effects of radiation on the NMR relaxation effects of aqueous solutions of gadolinium contrast agents.

Gultekin, David H.; Raidy, Thomas E.; Gore, John C.;
Open Access
  • Published: 01 Jan 2009 Journal: Contrast Media & Molecular Imaging, volume 4, pages 33-36 (issn: 1555-4309, eissn: 1555-4317, Copyright policy)
  • Publisher: Wiley
Abstract
We investigate the effects of radiation on aqueous solutions of two common MRI contrast agents based on paramagnetic gadolinium chelates. Aqueous solutions of Gd–DTPA (gadolinium diethylenetriaminepentaacetic acid) and Gd–HP-DO3A (gadoteridol), as well as Gd–DTPA in the presence of concentrations of several common metabolites (N-acetylaspartate, Choline, Creatine and myo-inositol) typical of conditions in vivo, were irradiated at dose levels up to 30 Gy using a 6 MV linear accelerator and imaged using a 1.5 T MRI system. In addition, the effects of radiation dose on solution relaxation rates were compared with the effects of temperature by subjecting the same sa...
Subjects
free text keywords: Radiology Nuclear Medicine and imaging, Nuclear magnetic resonance, Aqueous solution, Irradiation, Relaxation (NMR), Nuclear magnetic resonance spectroscopy, Chemistry, In vivo, Gadolinium, chemistry.chemical_element, Chelation, Gadoteridol, medicine.drug, medicine, Article
Related Organizations
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . Other literature type . 2009

Effects of radiation on the NMR relaxation effects of aqueous solutions of gadolinium contrast agents.

Gultekin, David H.; Raidy, Thomas E.; Gore, John C.;