publication . Article . Other literature type . 2014

Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease

Gilsbach R; Preissl S; Ba, Grüning; Schnick T; Burger L; Benes V; Würch A; Bönisch U; Günther S; Rolf Backofen; ...
  • Published: 22 Oct 2014
  • Publisher: Springer Nature
Abstract
DNA methylation is essential for proper gene expression, development and genome stability. Here the authors present whole-genome DNA methylation analyses of purified mouse cardiomyocytes from newborn, adult and failing hearts and find highly dynamic patterns between the three phenotypes of cardiomyocytes.
Subjects
free text keywords: Article, General Biochemistry, Genetics and Molecular Biology, General Physics and Astronomy, General Chemistry, CpG site, Molecular biology, Gene expression profiling, DNA methylation, Gene expression, Gene silencing, Cellular differentiation, DNA, chemistry.chemical_compound, chemistry, Genetics, Histone, biology.protein, biology
69 references, page 1 of 5

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Senyo S. E.et al.Mammalian heart renewal by pre-existing cardiomyocytes. Nature 493, 433–436 (2013).23222518 [OpenAIRE] [PubMed]

Taegtmeyer H., Sen S. & Vela D. Return to the fetal gene program: a suggested metabolic link to gene expression in the heart. Ann. NY Acad. Sci. 1188, 191–198 (2010).20201903 [OpenAIRE] [PubMed]

Siedner S.et al.Developmental changes in contractility and sarcomeric proteins from the early embryonic to the adult stage in the mouse heart. J. Physiol.548, 493–505 (2003).12640016 [OpenAIRE] [PubMed]

Krüger M., Kohl T. & Linke W. A. Developmental changes in passive stiffness and myofilament ca2+ sensitivity due to titin and troponin-i isoform switching are not critically triggered by birth. Am. J. Physiol. Heart Circ. Physiol. 291, H496–H506 (2006).16679402 [PubMed]

Grueter C. E.et al.A cardiac microrna governs systemic energy homeostasis by regulation of med13. Cell 149, 671–683 (2012).22541436 [OpenAIRE] [PubMed]

Anand P.et al.Bet bromodomains mediate transcriptional pause release in heart failure. Cell 154, 569–582 (2013).23911322 [OpenAIRE] [PubMed]

Wamstad J. A.et al.Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage. Cell 151, 206–220 (2012).22981 692 [OpenAIRE] [PubMed]

Zhang C. L.et al.Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell 110, 479–488 (2002).12202037 [OpenAIRE] [PubMed]

Hon G. C.et al.Epigenetic memory at embryonic enhancers identified in DNA methylation maps from adult mouse tissues. Nat. Genet.45, 1198–1206 (2013).23995138 [OpenAIRE] [PubMed]

Bird A.DNA methylation patterns and epigenetic memory. Genes Dev.16, 6–21 (2002).11782440 [PubMed]

Jones P. A.Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat. Rev. Genet.13, 484–492 (2012).22641018 [OpenAIRE] [PubMed]

Deaton A. M. & Bird A. Cpg islands and the regulation of transcription. Genes Dev. 25, 1010–1022 (2011).21576262 [OpenAIRE] [PubMed]

Smith Z. D. & Meissner A. DNA methylation: Roles in mammalian development. Nat. Rev. Genet. 14, 204–220 (2013).23400093 [PubMed]

Reik W., Dean W. & Walter J. Epigenetic reprogramming in mammalian development. Science 293, 1089–1093 (2001).11498579 [OpenAIRE] [PubMed]

69 references, page 1 of 5
Abstract
DNA methylation is essential for proper gene expression, development and genome stability. Here the authors present whole-genome DNA methylation analyses of purified mouse cardiomyocytes from newborn, adult and failing hearts and find highly dynamic patterns between the three phenotypes of cardiomyocytes.
Subjects
free text keywords: Article, General Biochemistry, Genetics and Molecular Biology, General Physics and Astronomy, General Chemistry, CpG site, Molecular biology, Gene expression profiling, DNA methylation, Gene expression, Gene silencing, Cellular differentiation, DNA, chemistry.chemical_compound, chemistry, Genetics, Histone, biology.protein, biology
69 references, page 1 of 5

Bergmann O.et al.Evidence for cardiomyocyte renewal in humans. Science 324, 98–102 (2009).19342590 [OpenAIRE] [PubMed]

Senyo S. E.et al.Mammalian heart renewal by pre-existing cardiomyocytes. Nature 493, 433–436 (2013).23222518 [OpenAIRE] [PubMed]

Taegtmeyer H., Sen S. & Vela D. Return to the fetal gene program: a suggested metabolic link to gene expression in the heart. Ann. NY Acad. Sci. 1188, 191–198 (2010).20201903 [OpenAIRE] [PubMed]

Siedner S.et al.Developmental changes in contractility and sarcomeric proteins from the early embryonic to the adult stage in the mouse heart. J. Physiol.548, 493–505 (2003).12640016 [OpenAIRE] [PubMed]

Krüger M., Kohl T. & Linke W. A. Developmental changes in passive stiffness and myofilament ca2+ sensitivity due to titin and troponin-i isoform switching are not critically triggered by birth. Am. J. Physiol. Heart Circ. Physiol. 291, H496–H506 (2006).16679402 [PubMed]

Grueter C. E.et al.A cardiac microrna governs systemic energy homeostasis by regulation of med13. Cell 149, 671–683 (2012).22541436 [OpenAIRE] [PubMed]

Anand P.et al.Bet bromodomains mediate transcriptional pause release in heart failure. Cell 154, 569–582 (2013).23911322 [OpenAIRE] [PubMed]

Wamstad J. A.et al.Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage. Cell 151, 206–220 (2012).22981 692 [OpenAIRE] [PubMed]

Zhang C. L.et al.Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell 110, 479–488 (2002).12202037 [OpenAIRE] [PubMed]

Hon G. C.et al.Epigenetic memory at embryonic enhancers identified in DNA methylation maps from adult mouse tissues. Nat. Genet.45, 1198–1206 (2013).23995138 [OpenAIRE] [PubMed]

Bird A.DNA methylation patterns and epigenetic memory. Genes Dev.16, 6–21 (2002).11782440 [PubMed]

Jones P. A.Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat. Rev. Genet.13, 484–492 (2012).22641018 [OpenAIRE] [PubMed]

Deaton A. M. & Bird A. Cpg islands and the regulation of transcription. Genes Dev. 25, 1010–1022 (2011).21576262 [OpenAIRE] [PubMed]

Smith Z. D. & Meissner A. DNA methylation: Roles in mammalian development. Nat. Rev. Genet. 14, 204–220 (2013).23400093 [PubMed]

Reik W., Dean W. & Walter J. Epigenetic reprogramming in mammalian development. Science 293, 1089–1093 (2001).11498579 [OpenAIRE] [PubMed]

69 references, page 1 of 5
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publication . Article . Other literature type . 2014

Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease

Gilsbach R; Preissl S; Ba, Grüning; Schnick T; Burger L; Benes V; Würch A; Bönisch U; Günther S; Rolf Backofen; ...