publication . Article . Other literature type . 1997

Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas

Chi, D. D. J.; Merchant, R. E.; Rand, R.; Conrad, A. J.; Garrison, D.; Turner, R.; Morton, D. L.; Dave Hoon;
  • Published: 01 Jun 1997
Abstract
Both melanocytes and glial cells are derived embryologically from the neural ectoderm. Their malignant transformed counterparts, melanoma and glioma cells, respectively, may share common antigens. Numerous tumor-associated antigens have been identified in melanomas but only a few a gliomas. Using an established reverse transcriptase polymerase chain reaction plus Southern blot assay, we compared the mRNA expression of melanoma-associated antigens (MAAs) of melanomas to brain tumors primarily derived from glial cells. The MAAs studied included tyrosinase (Tyr), tyrosinase-related protein-1 and -2 (TRP-1 and TRP-2), gp100, human melanoma antigen-encoding genes 1 a...
Subjects
Medical Subject Headings: neoplasmsotorhinolaryngologic diseases
free text keywords: Research Article
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Other literature type . 1997
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publication . Article . Other literature type . 1997

Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas

Chi, D. D. J.; Merchant, R. E.; Rand, R.; Conrad, A. J.; Garrison, D.; Turner, R.; Morton, D. L.; Dave Hoon;