Norepinephrine and its metabolites are involved in the synthesis of neuromelanin derived from the locus coeruleus

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Wakamatsu, Kazumasa ; Tabuchi, Keisuke ; Ojika, Makoto ; Zucca, Fabio A. ; Zecca, Luigi ; Ito, Shosuke (2015)
  • Publisher: John Wiley and Sons Inc.
  • Journal: Journal of Neurochemistry, volume 135, issue 4, pages 768-776 (issn: 0022-3042, eissn: 1471-4159)
  • Related identifiers: pmc: PMC5014224, doi: 10.1111/jnc.13237
  • Subject: Original Article | substantia nigra | HCl hydrolysis | ORIGINAL ARTICLES | neuromelanin | locus coeruleus | Bioenergetics & Metabolism | Parkinson's disease

Abstract In order to elucidate the chemical structure of black to brown pigments, neuromelanins (NMs), in the substantia nigra (SN) and the locus coeruleus (LC) in the central nervous system of humans and other mammalian species during aging, chemical degradative method... View more
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