publication . Other literature type . Article . 2018

Leucine signaling in the pathogenesis of type 2 diabetes and obesity

Bodo C Melnik;
Open Access English
  • Published: 13 Nov 2018
  • Publisher: Baishideng Publishing Group Co., Limited
Abstract
Epidemiological evidence points to increased dairy and meat consumption, staples of the Western diet, as major risk factors for the development of type 2 diabetes (T2D). This paper presents a new concept and comprehensive review of leucine-mediated cell signaling explaining the pathogenesis of T2D and obesity by leucine-induced over-stimulation of mammalian target of rapamycin complex 1 (mTORC1). mTORC1, a pivotal nutrient-sensitive kinase, promotes growth and cell proliferation in response to glucose, energy, growth factors and amino acids. Dairy proteins and meat stimulate insulin/insulin-like growth factor 1 signaling and provide high amounts of leucine, a pr...
Subjects
Medical Subject Headings: biological phenomena, cell phenomena, and immunity
free text keywords: Review, Biology, Adipogenesis, Insulin resistance, medicine.disease, medicine, Endocrinology, medicine.medical_specialty, mTORC1, Internal medicine, Insulin receptor, biology.protein, P70-S6 Kinase 1, Insulin, medicine.medical_treatment, Cell signaling, Type 2 diabetes
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