publication . Article . Other literature type . 2009

Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

Abbas Dehghan;
  • Published: 13 Jul 2009
Abstract
We conducted meta-analyses of genome-wide association studies (GWAS) for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a novel locus for AF (ZFHX3, rs2106261, risk ratio [RR]=1.19; P=2.3×10−7), an association that was replicated in the German AF Network (odds ratio=1.44; P=1.6×10−11). Combining the discovery and replication results, rs2106261 was significantly associated with AF (RR=1.25; P=1.8×10−15).
Subjects
free text keywords: Genetics, Odds ratio, Atrial fibrillation, medicine.disease, medicine, Genetic association, Genome-wide association study, Relative risk, Biology, Internal medicine, medicine.medical_specialty, Cohort, Meta-analysis, Article, epidemiology, polymorphism, single nucleotide
Funded by
NIH| CCSP - FIELD CENTER AND ULTRASOUND READING CENTER
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: N01HC055018-017
  • Funding stream: DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS
,
NIH| COMMUNITY AND COHORT SURVEILLANCE PROGRAMS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: N01HC055015-028
  • Funding stream: DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS
,
NIH| MRI READING CENTER FOR THE CARDIOVASCULAR HEALTH STUDY
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: N01HC015103-007
  • Funding stream: DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS
,
NIH| Diabetes Endocrinology Research Center
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3P30DK063491-04S1
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
,
NIH| Institute for Clinical and Translational Research (UL1)
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3UL1RR025005-03S2
  • Funding stream: NATIONAL CENTER FOR RESEARCH RESOURCES

Lloyd-Jones, DM. Circulation. 2004; 110: 1042-1046 [PubMed]

Heeringa, J. Eur Heart J. 2006; 27: 949-953 [PubMed]

Miyasaka, Y. Circulation. 2006; 114: 119-125 [PubMed]

Stewart, S. Am J Med. 2002; 113: 359-364 [PubMed]

Ellinor, PT. Hum Gene t. 2005; 118: 179-184

Fox, CS. JAMA. 2004; 291: 2851-2855 [OpenAIRE] [PubMed]

Gudbjartsson, DF. Nature. 2007; 448: 353-357 [PubMed]

Psaty, BM. Circ Cardiovasc Genet. 2009; 2: 73-80 [OpenAIRE] [PubMed]

Berry, FB. J Biol Chem. 2001; 276: 25057-25065 [PubMed]

Jung, CG. Development. 2005; 132: 5137-5145 [OpenAIRE] [PubMed]

Sun, X. Nat Genet. 2005; 37: 407-412 [OpenAIRE] [PubMed]

Burgner, D. PLoS Genet. 2009; 5: e1000319 [OpenAIRE] [PubMed]

Ido, A. Gene. 1996; 168: 227-231 [PubMed]

Hodgson-Zingman, DM. N Engl J Med. 2008; 359: 158-165 [OpenAIRE] [PubMed]

Abstract
We conducted meta-analyses of genome-wide association studies (GWAS) for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a novel locus for AF (ZFHX3, rs2106261, risk ratio [RR]=1.19; P=2.3×10−7), an association that was replicated in the German AF Network (odds ratio=1.44; P=1.6×10−11). Combining the discovery and replication results, rs2106261 was significantly associated with AF (RR=1.25; P=1.8×10−15).
Subjects
free text keywords: Genetics, Odds ratio, Atrial fibrillation, medicine.disease, medicine, Genetic association, Genome-wide association study, Relative risk, Biology, Internal medicine, medicine.medical_specialty, Cohort, Meta-analysis, Article, epidemiology, polymorphism, single nucleotide
Funded by
NIH| CCSP - FIELD CENTER AND ULTRASOUND READING CENTER
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: N01HC055018-017
  • Funding stream: DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS
,
NIH| COMMUNITY AND COHORT SURVEILLANCE PROGRAMS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: N01HC055015-028
  • Funding stream: DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS
,
NIH| MRI READING CENTER FOR THE CARDIOVASCULAR HEALTH STUDY
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: N01HC015103-007
  • Funding stream: DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS
,
NIH| Diabetes Endocrinology Research Center
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3P30DK063491-04S1
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
,
NIH| Institute for Clinical and Translational Research (UL1)
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3UL1RR025005-03S2
  • Funding stream: NATIONAL CENTER FOR RESEARCH RESOURCES

Lloyd-Jones, DM. Circulation. 2004; 110: 1042-1046 [PubMed]

Heeringa, J. Eur Heart J. 2006; 27: 949-953 [PubMed]

Miyasaka, Y. Circulation. 2006; 114: 119-125 [PubMed]

Stewart, S. Am J Med. 2002; 113: 359-364 [PubMed]

Ellinor, PT. Hum Gene t. 2005; 118: 179-184

Fox, CS. JAMA. 2004; 291: 2851-2855 [OpenAIRE] [PubMed]

Gudbjartsson, DF. Nature. 2007; 448: 353-357 [PubMed]

Psaty, BM. Circ Cardiovasc Genet. 2009; 2: 73-80 [OpenAIRE] [PubMed]

Berry, FB. J Biol Chem. 2001; 276: 25057-25065 [PubMed]

Jung, CG. Development. 2005; 132: 5137-5145 [OpenAIRE] [PubMed]

Sun, X. Nat Genet. 2005; 37: 407-412 [OpenAIRE] [PubMed]

Burgner, D. PLoS Genet. 2009; 5: e1000319 [OpenAIRE] [PubMed]

Ido, A. Gene. 1996; 168: 227-231 [PubMed]

Hodgson-Zingman, DM. N Engl J Med. 2008; 359: 158-165 [OpenAIRE] [PubMed]

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