publication . Bachelor thesis . 2014

IL-34 Expression in Gingival Fibroblasts, Gingival Crevicular Fluid and Gingival Tissue

Kreidly, Mariam;
Open Access English
  • Published: 01 Jan 2014
  • Publisher: Umeå universitet, Tandläkarutbildning
  • Country: Sweden
Abstract
IL-34 is a protein associated with bone degenerative diseases but the role in periodontal disease is unknown. The aim of this study was to assess the expression of IL-34 in primary human gingival fibroblasts (GF) and investigate if the expression is regulated by the pro-inflammatory cytokines interleukin-1 (IL-1β) and tumor necrosis factor α(TNF-α). We also investigated if IL-34 is detectible in gingival crevicular fluid (GCF) in healthy, gingivitis and periodontitis sites. Furthermore, we examined if healthy and inflamed gingival tissue contains IL-34. GF were stimulated by IL-1β300 pg/ml and TNF-α10 ng/ml. IL-34 mRNA was measured by quantitative real-time PCR...
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