publication . Doctoral thesis . 2011

Assessment of cerebrospinal fluid system dynamics : novel infusion protocol, mathematical modelling and parameter estimation for hydrocephalus investigations

Andersson, Kennet;
Open Access English
  • Published: 01 Jan 2011
  • Publisher: Umeå universitet, Radiofysik
  • Country: Sweden
Abstract
Patients with idiopathic normal pressure hydrocephalus (INPH) have a disturbance in the cerebrospinal fluid (CSF) system. The treatment is neurosurgical – a shunt is placed in the CSF system. The infusion test is used to assess CSF system dynamics and to aid in the selection of patients that will benefit from shunt surgery. The infusion test can be divided into three parts: a mathematical model, an infusion protocol and a parameter estimation method. A non-linear differential equation is used to mathematically describe the CSF system, where two important parameters are the outflow conductance (Cout) and the Pressure Volume Index (PVI). These are used both for cl...
Subjects
free text keywords: Medicinsk teknik, hydrocefalus, infusionstest, utflödeskonduktans, systemidentifiering, Biomedical Laboratory Science/Technology, Biomedicinsk laboratorievetenskap/teknologi
Related Organizations

Irani DN. Cerebrospinal Fluid in Clinical Practice: Elsevier, 2009 Marmarou A. Foreword. Neurosurgery. 2005;57:S2-i Relkin N, Marmarou A, Klinge P et al. Diagnosing idiopathic normal-pressure hydrocephalus.

Neurosurgery. 2005;57:S4-16; discussion ii-v Bergsneider M, Black PM, Klinge P et al. Surgical management of idiopathic normal-pressure hydrocephalus. Neurosurgery. 2005;57:S29-39; discussion ii-v The Department of Radiation Sciences, for making this research possible, and Anna Wernblom, secretary at the Department of Radiation Sciences, always willing to assist in whatever questions I've had.

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