publication . Doctoral thesis . 2012

Effekter av cannabinoider på cancerceller, neuronal differentiering och embryonal utveckling

Gustafsson, Sofia;
Open Access English
  • Published: 01 Jan 2012
  • Publisher: Umeå universitet, Farmakologi
  • Country: Sweden
Abstract
Cannabinoids (CBs) are compounds that activate the CB1 and CB2 receptors. CB receptors mediate many different physiological functions, and cannabinoids have been reported to decrease tumor cell viability, proliferation, migration, as well as to modulate metastasis. In this thesis, the effects of cannabinoids on human colorectal carcinoma Caco-2 cells (Paper I) and mouse P19 embryonal carcinoma (EC) cells (Paper III) were studied.  In both cell lines, the compounds examined produced a concentration- and time-dependent decrease in cell viability. In Caco-2-cells, HU 210 and the pyrimidine antagonist 5-fluorouracil produced synergistic effects upon cell viability. ...
Subjects
free text keywords: Cannabinoids, cell viability, neuronal differentiation, colorectal cancer, chick embryo, Pharmacology and Toxicology, Farmakologi och toxikologi
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