publication . Article . 2015

Metal-Free N-Arylation of Secondary Amides at Room Temperature

Fredrik Tinnis; Elin Stridfeldt; Helena Lundberg; Hans Adolfsson; Berit Olofsson;
Open Access
  • Published: 24 Sep 2015 Journal: Organic Letters, volume 17, pages 2,688-2,691 (issn: 1523-7060, eissn: 1523-7052, Copyright policy)
  • Publisher: American Chemical Society (ACS)
  • Country: Sweden
Abstract
The arylation of secondary acyclic amides has been achieved with diaryliodonium salts under mild and metal-free conditions. The methodology has a wide scope, allows synthesis of tertiary amides with highly congested aryl moieties, and avoids the regioselectivity problems observed in reactions with (diacetoxyiodo)benzene.
Subjects
free text keywords: Organisk kemi, Physical and Theoretical Chemistry, Organic Chemistry, Biochemistry, Aryl, chemistry.chemical_compound, chemistry, Regioselectivity, Metal, visual_art.visual_art_medium, visual_art, Benzene
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