publication . Bachelor thesis . 2005

Synthesis of Structures Related to Antifreeze Glycoproteins

Fyrner, Timmy;
Open Access English
  • Published: 01 Jan 2005
  • Publisher: Linköpings universitet, Institutionen för fysik, kemi och biologi
  • Country: Sweden
In this thesis, synthesis of structures related to antifreeze glycoproteins (AFGPs) are presented. Synthetic routes to a protected carbohydrate derivative, 2,3,4,6-tetra-O-benzyl-β-galactopyranosyl-(1→3)-2-deoxy-2-azido-4,6-di-O-benzyl-β-D-thio-1-galactopyranoside, and a tBu-Ala-Thr-Ala-Fmoc tripeptide, are described. These compounds are meant to be used in the assembly of AFGPs and analogues thereof. A Gal-GlcN disaccharide was synthesized via glycosylation between the donor, bromo-2-O-benzoyl-3,4,6-tri-O-benzyl-α-Dgalactopyranoside, and acceptor, ethyl 4,6-O-benzylidene-2-deoxy-2-N-phthalimido-β-D-1-thio-glucopyranoside, using silver triflate activation. Subse...
free text keywords: Organic chemistry, Organisk kemi
Related Organizations

9. Clemmings, J.F., Zoerb, H.F., Rosenwald, D.R.; Huang, V.T. Trends Food Sci. Technol. 1992, 8, 425.

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