publication . Doctoral thesis . 2008

Cyclooxygenase-2 inhibitors and knee prosthesis surgery

Meunier, Andreas;
Open Access English
  • Published: 01 Jan 2008
  • Publisher: Linköpings universitet, Ortopedi och idrottsmedicin
  • Country: Sweden
Abstract
Adverse effects of cyclooxygenase (COX) inhibitors on bone healing have previously been demonstrated in diaphyseal fracture models in animals. In spite of that, they are widely used as postoperative analgesics in orthopaedic surgery. After joint replacement, a bone repair process starts at the interface between bone and cement. If this process is disturbed, the prosthesis may never become rigidly fixed to the bone, leading to migration and with time loosening. This thesis investigates the effects of a selective COX-2 inhibitor (parecoxib or celecoxib) on bone healing in metaphyseal bone in a rat model and on knee prosthesis migration after total knee replacement...
Subjects
Medical Subject Headings: musculoskeletal diseases
free text keywords: Non-steroidal anti-inflammatory agents, administration & dosage, Arthroplasty, knee replacement, Surgical blood loss, Surgery, Cyclooxygenase inhibitors, Fracture healing, Isoxazoles, Postoperative pain, Pyrazoles, Sulfonamides, Kirurgi

Tengvall P, Skoglund B, Askendal A, Aspenberg P: Surface immobilized bisphosphonate improves stainless-steel screw fixation in rats. Biomaterials, 25(11): 2133-8, 2004.

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