publication . Article . 2001

Caspases: more than just killers?

Christopher Stroh; Reiner U. Jänicke; Klaus Schulze-Osthoff; Marek Los; Ingo H. Engels;
Open Access English
  • Published: 01 Jan 2001
  • Publisher: Department of Immunology and Cell Biology, University of Münster, Münster, Germany
  • Country: Sweden
Proteases of the caspase family constitute the central executioners of apoptosis. Several recent observations suggest that caspases and apoptosis-regulatory molecules exert important functions beyond that of cell death, including the control of T-cell proliferation and cell-cycle progression. Here, Los and colleagues propose a model that directly connects cell suicide mechanisms to the regulation of cell-cycle progression.
free text keywords: activation, Apoptosis, Bcl-2, cycle entry, death, division, fadd/mort1, inhibitor, Mice, t-cell proliferation, Biochemistry and Molecular Biology, Biokemi och molekylärbiologi, Cell Biology, Cellbiologi, Immunology, Immunology and Allergy, Cell cycle, Proteases, FADD, biology.protein, biology, Programmed cell death, Caspase, Intrinsic apoptosis
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