publication . Article . 2011

Th1 and Th2 chemokines, vaccine induced 1 immunity and allergic disease in infants  after maternal ω-3 fatty acid supplementation during pregnancy and lactation

Furuhjelm, Catrin; Jenmalm, Maria C.; Fälth-Magnusson, Karin; Duchén, Karel;
Open Access English
  • Published: 01 Jan 2011
  • Publisher: Linköpings universitet, Pediatrik
  • Country: Sweden
Abstract
We investigated whether the previously reported preventive effect of maternal ω-3 fatty acid supplementation on IgE-associated allergic disease in infancy may be mediated by facilitating a balanced circulating Th2/Th1 chemokine profile in the infant. Vaccine-induced immune responses at 2 y of age were also evaluated. Pregnant women, at risk of having an allergic infant, were randomized to daily supplementation with 1.6 g eicosapentaenoic acid and 1.1 g docosahexaenoic acid or placebo from the 25th gestational week through 3.5 mo of breastfeeding. Infant plasma was analyzed for chemokines (cord blood, 3, 12, 24 mo) and anti-tetanus and anti-diphtheria IgG (24 mo)...
Subjects
free text keywords: Medical and Health Sciences, Medicin och hälsovetenskap
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