publication . Doctoral thesis . 2012

Central Nervous System and Innate Immune Mechanisms for Inflammation- and Cancer-induced Anorexia

Ruud, Johan;
Open Access English
  • Published: 01 Jan 2012
  • Publisher: Linköping
Abstract
Anyone who has experienced influenza or a bacterial infection knows what it means to be ill. Apart from feeling feverish, experiencing aching joints and muscles, you lose the desire to eat. Anorexia, defined as loss of appetite or persistent satiety leading to reduced energy intake, is a hallmark of acute inflammatory disease. The anorexia is part of the acute phase response, triggered as the result of activation of the innate immune system with concomitant release of inflammatory mediators, which interact with the central nervous system. A chronic condition, and a severe medical problem, that resembles inflammation-induced anorexia is cachexia. Cachexia, which ...
Subjects
free text keywords: Medical and Health Sciences, Medicin och hälsovetenskap
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