publication . Doctoral thesis . 2007

Impact of Secondary Interactions in Asymmetric Catalysis

Frölander, Anders;
Open Access English
  • Published: 01 Jan 2007
  • Publisher: KTH, Organisk kemi
  • Country: Sweden
Abstract
This thesis deals with secondary interactions in asymmetric catalysis and their impact on the outcome of catalytic reactions. The first part revolves around the metal-catalyzed asymmetric allylic alkylation reaction and how interactions within the catalyst affect the stereochemistry. An OH–Pd hydrogen bond in Pd(0)–π-olefin complexes of hydroxy-containing oxazoline ligands was identified by density functional theory computations and helped to rationalize the contrasting results obtained employing hydroxy- and methoxy-containing ligands in the catalytic reaction. This type of hydrogen bond was further studied in phenanthroline metal complexes. As expected for a h...
Subjects
free text keywords: asymmetric catalysis, secondary interaction, hydrogen bond, chiral ligand, allylic alkylation, hydrosilylation, cyanation, pymox, box, PHOX, pybox, palladium, iridium, rhodium, Lewis acid, Lewis base, Organic chemistry, Organisk kemi
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